NFL Week2 Sunday 9/14 1 PM EST: San Francisco 49ers @ New Orleans Saints

September 10, 2025

Opening Line: 49ers - 7 O/U 44.5

Current Line: 49ers -3 O/U 40.5

Betting Splits: 49ers - 76% Bets, 71% Handle Saints - 24% Bets, 29% Handle

O/U: OVER - 39% Bets, 44% Handle UNDER - 61% Bets, 56% Handle

49ers are 2-8 ATS in its last 10 games.
49ers are 6-2-1 ATS in its L9 games vs the Saints.
Total has gone OVER in 4 of San Francisco's last 6 games.
49ers are 4-8 SU in its L12 games when playing on the road vs the Saints.
Total has gone UNDER in 4 of San Francisco's last 6 games when playing as the favorite
Saints are 4-10 ATS in its last 14 games.
Saints are 1-5 ATS in its last 6 games against the NFC West
Total has gone UNDER in 10 of the Saints last 14 games played in September.
49ers have covered the 1st Qtr Spread in 13 of their last 18 games: +8.35 Units / 41% ROI
49ers have hit the 2nd Half Game Total Over in 10 of their last 12 games: +7.75 Units / 59% ROI
49ers have hit the Game Total Over in 13 of their last 20 games: +5.30 Units / 24% ROI

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